Drug interactions
Tolmetin + Voclosporin
Severity: Major
Tolmetin and Voclosporin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin is a calcineurin inhibitor that can reduce glomerular filtration, and NSAIDs further compromise renal perfusion. The combination raises the risk of acute kidney injury.
What this interaction means in plain words
Tolmetin and Voclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Tolmetin belongs to Musculoskeletal; Voclosporin belongs to Miscellaneous.
Why it happens
Additive renal vasoconstriction from calcineurin inhibition and prostaglandin synthesis inhibition.
What to do
Avoid NSAIDs where possible in patients on voclosporin, which is used in lupus nephritis. If unavoidable, monitor eGFR and creatinine closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Tolmetin with Voclosporin?
MediHelp rates the interaction as major. Tolmetin and Voclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Voclosporin is a calcineurin inhibitor that can reduce glomerular filtration, and NSAIDs further compromise renal perfusion. The combination raises the risk of acute kidney injury.
How serious is the interaction between Tolmetin and Voclosporin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid NSAIDs where possible in patients on voclosporin, which is used in lupus nephritis. If unavoidable, monitor eGFR and creatinine closely.
What other medicines interact with Tolmetin?
MediHelp also lists interactions of Tolmetin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Tolmetin page.
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