Drug interactions
Tolterodine + Voxelotor
Severity: Minor
Tolterodine and Voxelotor: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voxelotor can increase exposure to sensitive CYP3A4 substrates. Tolterodine is only partly cleared by CYP3A4, so the effect is likely modest in most patients but may matter in CYP2D6 poor metabolizers.
What this interaction means in plain words
Tolterodine and Voxelotor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Tolterodine belongs to Genitourinary; Voxelotor belongs to Miscellaneous.
Why it happens
Voxelotor inhibits CYP3A4 and may reduce tolterodine clearance.
What to do
No routine dose change is needed in most patients; monitor for anticholinergic adverse effects, and consider reducing the tolterodine dose in CYP2D6 poor metabolizers.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolterodine
Other interactions of Voxelotor
- Amobarbital + Voxelotor Major
- Apalutamide + Voxelotor Major
- Carbamazepine + Voxelotor Major
- Cyclosporin + Voxelotor Major
- Efavirenz + Voxelotor Major
- Enzalutamide + Voxelotor Major
Frequently asked questions
Can I take Tolterodine with Voxelotor?
MediHelp rates the interaction as minor. Tolterodine and Voxelotor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Voxelotor can increase exposure to sensitive CYP3A4 substrates. Tolterodine is only partly cleared by CYP3A4, so the effect is likely modest in most patients but may matter in CYP2D6 poor metabolizers.
How serious is the interaction between Tolterodine and Voxelotor?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed in most patients; monitor for anticholinergic adverse effects, and consider reducing the tolterodine dose in CYP2D6 poor metabolizers.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
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