Drug interactions
Tolterodine + Ziprasidone
Severity: Major
Tolterodine and Ziprasidone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so combined use may add to the risk of torsades de pointes. Ziprasidone also has some anticholinergic activity that may add to tolterodine's effects. Cardiac risk is the main concern.
What this interaction means in plain words
Tolterodine and Ziprasidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Tolterodine belongs to Genitourinary; Ziprasidone belongs to Central Nervous System.
Why it happens
Additive QT prolongation and mild additive antimuscarinic effects.
What to do
Avoid the combination in patients with QT risk factors or electrolyte disturbances. Otherwise obtain a baseline ECG and correct potassium and magnesium before and during therapy.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tolterodine
Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Tolterodine with Ziprasidone?
MediHelp rates the interaction as major. Tolterodine and Ziprasidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, so combined use may add to the risk of torsades de pointes. Ziprasidone also has some anticholinergic activity that may add to tolterodine's effects. Cardiac risk is the main concern.
How serious is the interaction between Tolterodine and Ziprasidone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in patients with QT risk factors or electrolyte disturbances. Otherwise obtain a baseline ECG and correct potassium and magnesium before and during therapy.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
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