Drug interactions
Tolvaptan + Vinblastine
Severity: Minor
Tolvaptan and Vinblastine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tolvaptan inhibits P-glycoprotein in vitro and could raise vinblastine exposure. The clinical significance is not established and is likely small.
What this interaction means in plain words
Tolvaptan and Vinblastine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Tolvaptan belongs to Endocrine; Vinblastine belongs to Oncology.
Why it happens
Tolvaptan may inhibit P-glycoprotein efflux of vinblastine.
What to do
No routine adjustment is needed; monitor blood counts and for neurotoxicity as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Vinblastine
Other interactions of Tolvaptan
- Atazanavir + Tolvaptan Contraindicated
- Ceritinib + Tolvaptan Contraindicated
- Cobicistat + Tolvaptan Contraindicated
- Conivaptan + Tolvaptan Contraindicated
- Darunavir + Tolvaptan Contraindicated
- Idelalisib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Tolvaptan with Vinblastine?
MediHelp rates the interaction as minor. Tolvaptan and Vinblastine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tolvaptan inhibits P-glycoprotein in vitro and could raise vinblastine exposure. The clinical significance is not established and is likely small.
How serious is the interaction between Tolvaptan and Vinblastine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor blood counts and for neurotoxicity as usual.
What other medicines interact with Vinblastine?
MediHelp also lists interactions of Vinblastine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vinblastine page.
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