Drug interactions
Tolvaptan + Voxelotor
Severity: Moderate
Tolvaptan and Voxelotor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voxelotor inhibits CYP3A4 and can raise exposure to sensitive substrates such as tolvaptan. Higher levels increase the risk of excessive aquaresis and rapid sodium shifts.
What this interaction means in plain words
Tolvaptan and Voxelotor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tolvaptan belongs to Endocrine; Voxelotor belongs to Miscellaneous.
Why it happens
Inhibition of CYP3A4 reduces tolvaptan metabolism.
What to do
Monitor serum sodium and volume status closely, and consider reducing the tolvaptan dose if exposure appears excessive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolvaptan
- Atazanavir + Tolvaptan Contraindicated
- Ceritinib + Tolvaptan Contraindicated
- Cobicistat + Tolvaptan Contraindicated
- Conivaptan + Tolvaptan Contraindicated
- Darunavir + Tolvaptan Contraindicated
- Idelalisib + Tolvaptan Contraindicated
Other interactions of Voxelotor
- Amobarbital + Voxelotor Major
- Apalutamide + Voxelotor Major
- Carbamazepine + Voxelotor Major
- Cyclosporin + Voxelotor Major
- Efavirenz + Voxelotor Major
- Enzalutamide + Voxelotor Major
Frequently asked questions
Can I take Tolvaptan with Voxelotor?
MediHelp rates the interaction as moderate. Tolvaptan and Voxelotor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voxelotor inhibits CYP3A4 and can raise exposure to sensitive substrates such as tolvaptan. Higher levels increase the risk of excessive aquaresis and rapid sodium shifts.
How serious is the interaction between Tolvaptan and Voxelotor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum sodium and volume status closely, and consider reducing the tolvaptan dose if exposure appears excessive.
What other medicines interact with Tolvaptan?
MediHelp also lists interactions of Tolvaptan with, for example, Atazanavir, Ceritinib, Cobicistat. The full list is on the Tolvaptan page.
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