Drug interactions
Topotecan + Trastuzumab
Severity: Moderate
Topotecan and Trastuzumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trastuzumab combined with myelosuppressive chemotherapy such as topotecan is associated with more neutropenia and febrile neutropenia. This may raise the risk of infection.
What this interaction means in plain words
Topotecan and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Topotecan belongs to Oncology; Trastuzumab belongs to Oncology.
Why it happens
Additive pharmacodynamic myelosuppression, with trastuzumab increasing the neutropenic effect of cytotoxic chemotherapy.
What to do
Monitor neutrophil counts regularly and use dose modification or G-CSF support per protocol if neutropenia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Topotecan
- Adenovirus types 4 and 7 live + Topotecan Contraindicated
- Amiodarone + Topotecan Major
- Cisplatin + Topotecan Major
- Cobicistat + Topotecan Major
- Cyclosporine + Topotecan Major
- Cyclosporin + Topotecan Major
Other interactions of Trastuzumab
Frequently asked questions
Can I take Topotecan with Trastuzumab?
MediHelp rates the interaction as moderate. Topotecan and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trastuzumab combined with myelosuppressive chemotherapy such as topotecan is associated with more neutropenia and febrile neutropenia. This may raise the risk of infection.
How serious is the interaction between Topotecan and Trastuzumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neutrophil counts regularly and use dose modification or G-CSF support per protocol if neutropenia develops.
What other medicines interact with Topotecan?
MediHelp also lists interactions of Topotecan with, for example, Adenovirus types 4 and 7 live, Amiodarone, Cisplatin. The full list is on the Topotecan page.
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