Drug interactions
Topotecan + Vandetanib
Severity: Moderate
Topotecan and Vandetanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vandetanib inhibits P-glycoprotein and may raise topotecan exposure, especially with oral dosing. This could worsen myelosuppression and other toxicities.
What this interaction means in plain words
Topotecan and Vandetanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Topotecan belongs to Oncology; Vandetanib belongs to Oncology.
Why it happens
P-gp and possibly BCRP inhibition by vandetanib increases topotecan absorption and reduces elimination.
What to do
Avoid oral topotecan with vandetanib; with IV topotecan, monitor blood counts and adjust dose for toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Topotecan
- Adenovirus types 4 and 7 live + Topotecan Contraindicated
- Amiodarone + Topotecan Major
- Cisplatin + Topotecan Major
- Cobicistat + Topotecan Major
- Cyclosporine + Topotecan Major
- Cyclosporin + Topotecan Major
Other interactions of Vandetanib
- Amiodarone + Vandetanib Contraindicated
- Amisulpride + Vandetanib Contraindicated
- Amitriptyline + Vandetanib Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Asenapine + Vandetanib Contraindicated
- Chloroquine + Vandetanib Contraindicated
Frequently asked questions
Can I take Topotecan with Vandetanib?
MediHelp rates the interaction as moderate. Topotecan and Vandetanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vandetanib inhibits P-glycoprotein and may raise topotecan exposure, especially with oral dosing. This could worsen myelosuppression and other toxicities.
How serious is the interaction between Topotecan and Vandetanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid oral topotecan with vandetanib; with IV topotecan, monitor blood counts and adjust dose for toxicity.
What other medicines interact with Topotecan?
MediHelp also lists interactions of Topotecan with, for example, Adenovirus types 4 and 7 live, Amiodarone, Cisplatin. The full list is on the Topotecan page.
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