Drug interactions
Torsemide + Vilanterol / fluticasone furoate inhaled
Severity: Moderate
Torsemide and Vilanterol / fluticasone furoate inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilanterol, a beta-agonist, can lower serum potassium and prolong the QT interval, and torsemide also causes potassium loss. Together hypokalemia and ECG changes may be more likely, especially at excessive beta-agonist doses.
What this interaction means in plain words
Torsemide and Vilanterol / fluticasone furoate inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypokalemia from beta-2 stimulated intracellular potassium shift and loop diuretic renal potassium loss.
What to do
Monitor serum potassium and magnesium, particularly in patients with cardiac disease, and keep the beta-agonist at the recommended dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Torsemide
Frequently asked questions
Can I take Torsemide with Vilanterol / fluticasone furoate inhaled?
MediHelp rates the interaction as moderate. Torsemide and Vilanterol / fluticasone furoate inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vilanterol, a beta-agonist, can lower serum potassium and prolong the QT interval, and torsemide also causes potassium loss. Together hypokalemia and ECG changes may be more likely, especially at excessive beta-agonist doses.
How serious is the interaction between Torsemide and Vilanterol / fluticasone furoate inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium, particularly in patients with cardiac disease, and keep the beta-agonist at the recommended dose.
What other medicines interact with Torsemide?
MediHelp also lists interactions of Torsemide with, for example, Amikacin, Amiodarone, Carbenoxolone. The full list is on the Torsemide page.
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