Drug interactions
Trabectedin + Verapamil
Severity: Major
Trabectedin and Verapamil: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil, a moderate CYP3A4 inhibitor, may raise trabectedin exposure and increase toxicities such as hepatotoxicity, myelosuppression and rhabdomyolysis.
What this interaction means in plain words
Trabectedin and Verapamil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Trabectedin belongs to Oncology; Verapamil belongs to Cardiovascular.
Why it happens
Inhibition of CYP3A4-mediated trabectedin metabolism by verapamil.
What to do
Avoid the combination where possible, using a non-inhibiting antihypertensive or antiarrhythmic; otherwise monitor liver enzymes, CK and blood counts closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Trabectedin
Frequently asked questions
Can I take Trabectedin with Verapamil?
MediHelp rates the interaction as major. Trabectedin and Verapamil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Verapamil, a moderate CYP3A4 inhibitor, may raise trabectedin exposure and increase toxicities such as hepatotoxicity, myelosuppression and rhabdomyolysis.
How serious is the interaction between Trabectedin and Verapamil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, using a non-inhibiting antihypertensive or antiarrhythmic; otherwise monitor liver enzymes, CK and blood counts closely.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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