Drug interactions
Trandolapril + Treprostinil
Severity: Moderate
Trandolapril and Treprostinil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Treprostinil is a potent vasodilator, so combining it with trandolapril may produce additive blood pressure lowering. Symptomatic hypotension is possible, particularly at initiation or dose increases.
What this interaction means in plain words
Trandolapril and Treprostinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Trandolapril belongs to Cardiovascular; Treprostinil belongs to Cardiovascular.
Why it happens
Additive vasodilation and blood pressure reduction through different pathways.
What to do
Monitor blood pressure and symptoms of hypotension when starting or titrating either drug. Reduce the trandolapril dose if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trandolapril
- Aliskiren + Trandolapril Contraindicated
- Protein a column + Trandolapril Contraindicated
- Sacubitril / valsartan + Trandolapril Contraindicated
- Sacubitril-valsartan + Trandolapril Contraindicated
- Aldesleukin + Trandolapril Major
- Amifostine + Trandolapril Major
Other interactions of Treprostinil
Frequently asked questions
Can I take Trandolapril with Treprostinil?
MediHelp rates the interaction as moderate. Trandolapril and Treprostinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Treprostinil is a potent vasodilator, so combining it with trandolapril may produce additive blood pressure lowering. Symptomatic hypotension is possible, particularly at initiation or dose increases.
How serious is the interaction between Trandolapril and Treprostinil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and symptoms of hypotension when starting or titrating either drug. Reduce the trandolapril dose if hypotension occurs.
What other medicines interact with Trandolapril?
MediHelp also lists interactions of Trandolapril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Trandolapril page.
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