Drug interactions
Trastuzumab + Ustekinumab
Severity: Minor
Trastuzumab and Ustekinumab: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trastuzumab increases neutropenia when combined with chemotherapy, and ustekinumab modulates immunity, so infection risk may be somewhat higher. Direct interaction data between these two agents are lacking.
What this interaction means in plain words
Trastuzumab and Ustekinumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Trastuzumab belongs to Oncology; Ustekinumab belongs to Gastrointestinal Tract.
Why it happens
Possible additive immune effects; no established pharmacokinetic interaction.
What to do
Monitor for infection and neutropenia in patients also receiving chemotherapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ustekinumab
- Bcg vaccine live + Ustekinumab Contraindicated
- Typhoid vaccine live + Ustekinumab Contraindicated
- Adalimumab + Ustekinumab Major
- Adenovirus types 4 and 7 live + Ustekinumab Major
- Alefacept + Ustekinumab Major
- Anakinra + Ustekinumab Major
Other interactions of Trastuzumab
Frequently asked questions
Can I take Trastuzumab with Ustekinumab?
MediHelp rates the interaction as minor. Trastuzumab and Ustekinumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Trastuzumab increases neutropenia when combined with chemotherapy, and ustekinumab modulates immunity, so infection risk may be somewhat higher. Direct interaction data between these two agents are lacking.
How serious is the interaction between Trastuzumab and Ustekinumab?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for infection and neutropenia in patients also receiving chemotherapy.
What other medicines interact with Ustekinumab?
MediHelp also lists interactions of Ustekinumab with, for example, Bcg vaccine live, Typhoid vaccine live, Adalimumab. The full list is on the Ustekinumab page.
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