Drug interactions
Trastuzumab + Vinblastine
Severity: Moderate
Trastuzumab and Vinblastine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trastuzumab given with myelosuppressive chemotherapy has been associated with a higher incidence of neutropenia and febrile neutropenia. Combined use with vinblastine may raise infection risk.
What this interaction means in plain words
Trastuzumab and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Trastuzumab belongs to Oncology; Vinblastine belongs to Oncology.
Why it happens
Additive hematologic toxicity when trastuzumab is combined with cytotoxic chemotherapy; no pharmacokinetic interaction is established.
What to do
Monitor blood counts and for signs of infection, and use supportive care or dose delays according to protocol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vinblastine
Other interactions of Trastuzumab
Frequently asked questions
Can I take Trastuzumab with Vinblastine?
MediHelp rates the interaction as moderate. Trastuzumab and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trastuzumab given with myelosuppressive chemotherapy has been associated with a higher incidence of neutropenia and febrile neutropenia. Combined use with vinblastine may raise infection risk.
How serious is the interaction between Trastuzumab and Vinblastine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and for signs of infection, and use supportive care or dose delays according to protocol.
What other medicines interact with Vinblastine?
MediHelp also lists interactions of Vinblastine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vinblastine page.
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