Drug interactions
Trastuzumab emtansine + Voriconazole
Severity: Major
Trastuzumab emtansine and Voriconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole may raise exposure to DM1, the cytotoxic component released from trastuzumab emtansine. This can increase toxicities such as hepatotoxicity, thrombocytopenia and neuropathy.
What this interaction means in plain words
Trastuzumab emtansine and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Trastuzumab emtansine belongs to Oncology; Voriconazole belongs to Anti Fungals.
Why it happens
Strong CYP3A4 inhibition reduces metabolism of DM1.
What to do
Consider an alternative antifungal with less CYP3A4 inhibition. If unavoidable, delay the infusion until voriconazole has cleared and monitor closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Trastuzumab emtansine
Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Trastuzumab emtansine with Voriconazole?
MediHelp rates the interaction as major. Trastuzumab emtansine and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Voriconazole may raise exposure to DM1, the cytotoxic component released from trastuzumab emtansine. This can increase toxicities such as hepatotoxicity, thrombocytopenia and neuropathy.
How serious is the interaction between Trastuzumab emtansine and Voriconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative antifungal with less CYP3A4 inhibition. If unavoidable, delay the infusion until voriconazole has cleared and monitor closely.
What other medicines interact with Trastuzumab emtansine?
MediHelp also lists interactions of Trastuzumab emtansine with, for example, Clarithromycin, Itraconazole, Ketoconazole. The full list is on the Trastuzumab emtansine page.
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