Drug interactions
Treprostinil + Triamterene
Severity: Minor
Treprostinil and Triamterene: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Treprostinil is a vasodilator that lowers blood pressure, and diuretics like triamterene can add to this effect. Additive hypotension may occur, especially with volume depletion.
What this interaction means in plain words
Treprostinil and Triamterene have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Treprostinil belongs to Cardiovascular; Triamterene belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic hypotensive effects from vasodilation and diuresis.
What to do
Monitor blood pressure and volume status when starting or changing doses. Reduce the diuretic dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Triamterene
- Amiloride + Triamterene Contraindicated
- Eplerenone + Triamterene Contraindicated
- Potassium citrate / citric acid + Triamterene Contraindicated
- Potassium citrate + Triamterene Contraindicated
- Spironolactone + Triamterene Contraindicated
- Aceclofenac + Triamterene Major
Other interactions of Treprostinil
Frequently asked questions
Can I take Treprostinil with Triamterene?
MediHelp rates the interaction as minor. Treprostinil and Triamterene have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Treprostinil is a vasodilator that lowers blood pressure, and diuretics like triamterene can add to this effect. Additive hypotension may occur, especially with volume depletion.
How serious is the interaction between Treprostinil and Triamterene?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and volume status when starting or changing doses. Reduce the diuretic dose if symptomatic hypotension occurs.
What other medicines interact with Triamterene?
MediHelp also lists interactions of Triamterene with, for example, Amiloride, Eplerenone, Potassium citrate / citric acid. The full list is on the Triamterene page.
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