Drug interactions
Triamcinolone acetonide injectable + Voriconazole
Severity: Moderate
Triamcinolone acetonide injectable and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Strong CYP3A4 inhibitors can markedly increase systemic triamcinolone exposure after injection. Cases of iatrogenic Cushing syndrome and adrenal suppression have been described with related azole combinations.
What this interaction means in plain words
Triamcinolone acetonide injectable and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Voriconazole inhibits CYP3A4-mediated clearance of triamcinolone.
What to do
Monitor for corticosteroid excess such as Cushingoid features, hyperglycemia and adrenal suppression, especially with repeated injections. Consider a less CYP3A4-dependent corticosteroid or longer dosing intervals.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Triamcinolone acetonide injectable with Voriconazole?
MediHelp rates the interaction as moderate. Triamcinolone acetonide injectable and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Strong CYP3A4 inhibitors can markedly increase systemic triamcinolone exposure after injection. Cases of iatrogenic Cushing syndrome and adrenal suppression have been described with related azole combinations.
How serious is the interaction between Triamcinolone acetonide injectable and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for corticosteroid excess such as Cushingoid features, hyperglycemia and adrenal suppression, especially with repeated injections. Consider a less CYP3A4-dependent corticosteroid or longer dosing intervals.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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