Drug interactions
Triamcinolone + Zafirlukast
Severity: Minor
Triamcinolone and Zafirlukast: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zafirlukast inhibits CYP3A4 to a limited extent in vitro, so it could theoretically raise triamcinolone concentrations. A clinically important effect has not been well shown.
What this interaction means in plain words
Triamcinolone and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Triamcinolone belongs to Endocrine; Zafirlukast belongs to Respiratory.
Why it happens
Possible weak inhibition of CYP3A4-mediated triamcinolone metabolism by zafirlukast, not well established clinically.
What to do
No dose adjustment is usually needed; be alert for signs of corticosteroid excess if used with repeated high-dose triamcinolone.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Triamcinolone
- Smallpox vaccine live + Triamcinolone Contraindicated
- Triamcinolone + Zoster vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Triamcinolone Major
- Aldesleukin + Triamcinolone Major
- Atazanavir + Triamcinolone Major
- Axicabtagene ciloleucel + Triamcinolone Major
Other interactions of Zafirlukast
- Pimozide + Zafirlukast Contraindicated
- Lomitapide + Zafirlukast Major
- Nilotinib + Zafirlukast Major
- Warfarin + Zafirlukast Major
- Apalutamide + Zafirlukast Moderate
- Carbamazepine + Zafirlukast Moderate
Frequently asked questions
Can I take Triamcinolone with Zafirlukast?
MediHelp rates the interaction as minor. Triamcinolone and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Zafirlukast inhibits CYP3A4 to a limited extent in vitro, so it could theoretically raise triamcinolone concentrations. A clinically important effect has not been well shown.
How serious is the interaction between Triamcinolone and Zafirlukast?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed; be alert for signs of corticosteroid excess if used with repeated high-dose triamcinolone.
What other medicines interact with Triamcinolone?
MediHelp also lists interactions of Triamcinolone with, for example, Smallpox vaccine live, Zoster vaccine live, Adenovirus types 4 and 7 live. The full list is on the Triamcinolone page.
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