Drug interactions
Trifluoperazine + Voriconazole
Severity: Moderate
Trifluoperazine and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QT interval, so co-administration increases the risk of torsades de pointes. The risk is greater with electrolyte disturbance, structural heart disease or other QT-prolonging drugs.
What this interaction means in plain words
Trifluoperazine and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation through cardiac potassium channel blockade.
What to do
Get a baseline ECG and monitor QTc, and correct hypokalemia and hypomagnesemia. Consider an alternative if QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Trifluoperazine with Voriconazole?
MediHelp rates the interaction as moderate. Trifluoperazine and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can prolong the QT interval, so co-administration increases the risk of torsades de pointes. The risk is greater with electrolyte disturbance, structural heart disease or other QT-prolonging drugs.
How serious is the interaction between Trifluoperazine and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Get a baseline ECG and monitor QTc, and correct hypokalemia and hypomagnesemia. Consider an alternative if QTc becomes markedly prolonged.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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