Drug interactions
Tropisetron + Voriconazole
Severity: Moderate
Tropisetron and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tropisetron is a 5-HT3 antagonist with QT-prolonging potential and is metabolized by CYP2D6 and CYP3A4. Voriconazole adds QT prolongation and may raise tropisetron levels, increasing arrhythmia risk.
What this interaction means in plain words
Tropisetron and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation, with minor CYP3A4 inhibition raising tropisetron exposure.
What to do
Monitor ECG and correct hypokalemia and hypomagnesemia. Consider a 5-HT3 antagonist with lower QT risk in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Tropisetron with Voriconazole?
MediHelp rates the interaction as moderate. Tropisetron and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tropisetron is a 5-HT3 antagonist with QT-prolonging potential and is metabolized by CYP2D6 and CYP3A4. Voriconazole adds QT prolongation and may raise tropisetron levels, increasing arrhythmia risk.
How serious is the interaction between Tropisetron and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and correct hypokalemia and hypomagnesemia. Consider a 5-HT3 antagonist with lower QT risk in high-risk patients.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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