Drug interactions
Typhoid polysaccharide vaccine + Upadacitinib
Severity: Minor
Typhoid polysaccharide vaccine and Upadacitinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
This inactivated vaccine carries no infection risk, but upadacitinib may reduce the antibody response and protection.
What this interaction means in plain words
Typhoid polysaccharide vaccine and Upadacitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
JAK inhibition may blunt immune response to non-live vaccines.
What to do
The vaccine may be given, ideally at least two weeks before starting upadacitinib when feasible. Consider reinforcing precautions for travelers.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Upadacitinib
- Abrocitinib + Upadacitinib Contraindicated
- Adenovirus types 4 and 7 live + Upadacitinib Contraindicated
- Baricitinib + Upadacitinib Contraindicated
- Bcg vaccine live + Upadacitinib Contraindicated
- Cyclosporine + Upadacitinib Contraindicated
- Dengue vaccine + Upadacitinib Contraindicated
Frequently asked questions
Can I take Typhoid polysaccharide vaccine with Upadacitinib?
MediHelp rates the interaction as minor. Typhoid polysaccharide vaccine and Upadacitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. This inactivated vaccine carries no infection risk, but upadacitinib may reduce the antibody response and protection.
How serious is the interaction between Typhoid polysaccharide vaccine and Upadacitinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: The vaccine may be given, ideally at least two weeks before starting upadacitinib when feasible. Consider reinforcing precautions for travelers.
What other medicines interact with Upadacitinib?
MediHelp also lists interactions of Upadacitinib with, for example, Abrocitinib, Adenovirus types 4 and 7 live, Baricitinib. The full list is on the Upadacitinib page.
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