Drug interactions
Ublituximab + Ustekinumab
Severity: Moderate
Ublituximab and Ustekinumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ustekinumab (IL-12/23 inhibitor) and ublituximab (B-cell depleting) both impair immunity. Used together they may add to the risk of infection.
What this interaction means in plain words
Ublituximab and Ustekinumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ublituximab belongs to Miscellaneous; Ustekinumab belongs to Gastrointestinal Tract.
Why it happens
Additive immunosuppression from cytokine blockade and CD20 B-cell depletion.
What to do
Monitor for signs of infection and consider the prolonged effect of ublituximab when planning combined therapy. Screen for hepatitis B and tuberculosis as appropriate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ustekinumab
- Bcg vaccine live + Ustekinumab Contraindicated
- Typhoid vaccine live + Ustekinumab Contraindicated
- Adalimumab + Ustekinumab Major
- Adenovirus types 4 and 7 live + Ustekinumab Major
- Alefacept + Ustekinumab Major
- Anakinra + Ustekinumab Major
Other interactions of Ublituximab
Frequently asked questions
Can I take Ublituximab with Ustekinumab?
MediHelp rates the interaction as moderate. Ublituximab and Ustekinumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ustekinumab (IL-12/23 inhibitor) and ublituximab (B-cell depleting) both impair immunity. Used together they may add to the risk of infection.
How serious is the interaction between Ublituximab and Ustekinumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of infection and consider the prolonged effect of ublituximab when planning combined therapy. Screen for hepatitis B and tuberculosis as appropriate.
What other medicines interact with Ustekinumab?
MediHelp also lists interactions of Ustekinumab with, for example, Bcg vaccine live, Typhoid vaccine live, Adalimumab. The full list is on the Ustekinumab page.
Full monographs, dosing and an interaction checker in the MediHelp app
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