Drug interactions
Ublituximab + Zidovudine
Severity: Moderate
Ublituximab and Zidovudine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ublituximab depletes B cells and can increase the risk of infections, which is relevant in people with HIV. Zidovudine's antiviral effect is not reduced, but the added immunosuppression can complicate HIV management.
What this interaction means in plain words
Ublituximab and Zidovudine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ublituximab belongs to Miscellaneous; Zidovudine belongs to Anti Virals.
Why it happens
Pharmacodynamic: B-cell depletion by ublituximab increases infection risk; no direct effect on zidovudine pharmacokinetics.
What to do
Check hepatitis B status and HIV viral load and CD4 count before and during therapy, and monitor for infections.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zidovudine
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Zidovudine Contraindicated
- Stavudine + Zidovudine Contraindicated
- Atidarsagene autotemcel + Zidovudine Major
- Betibeglogene autotemcel + Zidovudine Major
- Carboplatin + Zidovudine Major
- Cisplatin + Zidovudine Major
Other interactions of Ublituximab
Frequently asked questions
Can I take Ublituximab with Zidovudine?
MediHelp rates the interaction as moderate. Ublituximab and Zidovudine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ublituximab depletes B cells and can increase the risk of infections, which is relevant in people with HIV. Zidovudine's antiviral effect is not reduced, but the added immunosuppression can complicate HIV management.
How serious is the interaction between Ublituximab and Zidovudine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check hepatitis B status and HIV viral load and CD4 count before and during therapy, and monitor for infections.
What other medicines interact with Zidovudine?
MediHelp also lists interactions of Zidovudine with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Stavudine, Atidarsagene autotemcel. The full list is on the Zidovudine page.
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