Drug interactions
Ulipristal + Voriconazole
Severity: Moderate
Ulipristal and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole may raise ulipristal concentrations since it is cleared by CYP3A4. Increased exposure could amplify adverse effects, although with single-dose emergency contraception the impact is likely limited.
What this interaction means in plain words
Ulipristal and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Voriconazole inhibits CYP3A4-mediated metabolism of ulipristal.
What to do
For emergency contraception, no dose change is typically required but counsel on adverse effects. Avoid prolonged ulipristal regimens with voriconazole unless monitored.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Ulipristal with Voriconazole?
MediHelp rates the interaction as moderate. Ulipristal and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole may raise ulipristal concentrations since it is cleared by CYP3A4. Increased exposure could amplify adverse effects, although with single-dose emergency contraception the impact is likely limited.
How serious is the interaction between Ulipristal and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: For emergency contraception, no dose change is typically required but counsel on adverse effects. Avoid prolonged ulipristal regimens with voriconazole unless monitored.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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