Drug interactions
Umeclidinium bromide / vilanterol inhaled + Voriconazole
Severity: Moderate
Umeclidinium bromide / vilanterol inhaled and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilanterol is a beta-agonist that can prolong QTc and cause tachycardia, and voriconazole can prolong QT. Voriconazole may also raise vilanterol exposure through CYP3A4 inhibition. Systemic exposure from inhalation is low, so the effect is usually modest.
What this interaction means in plain words
Umeclidinium bromide / vilanterol inhaled and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation, plus CYP3A4 inhibition increasing vilanterol exposure.
What to do
Monitor for palpitations and arrhythmia, and consider an ECG in patients with cardiac risk factors. Correct electrolytes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Umeclidinium bromide / vilanterol inhaled and Voriconazole, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Umeclidinium bromide / vilanterol inhaled with Voriconazole?
MediHelp rates the interaction as moderate. Umeclidinium bromide / vilanterol inhaled and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vilanterol is a beta-agonist that can prolong QTc and cause tachycardia, and voriconazole can prolong QT. Voriconazole may also raise vilanterol exposure through CYP3A4 inhibition. Systemic exposure from inhalation is low, so the effect is usually modest.
How serious is the interaction between Umeclidinium bromide / vilanterol inhaled and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for palpitations and arrhythmia, and consider an ECG in patients with cardiac risk factors. Correct electrolytes.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
