Drug interactions
Umeclidinium-vilanterol + Vandetanib
Severity: Major
Umeclidinium-vilanterol and Vandetanib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vandetanib markedly prolongs the QT interval and carries a risk of torsades de pointes. Vilanterol may add to this effect and lower potassium.
What this interaction means in plain words
Umeclidinium-vilanterol and Vandetanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Umeclidinium-vilanterol belongs to Respiratory; Vandetanib belongs to Oncology.
Why it happens
Additive QT prolongation with beta-2 agonist-associated hypokalemia.
What to do
Avoid concurrent use where possible and use an alternative bronchodilator. If unavoidable, monitor ECG, potassium, magnesium and calcium regularly.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Umeclidinium-vilanterol
Other interactions of Vandetanib
- Amiodarone + Vandetanib Contraindicated
- Amisulpride + Vandetanib Contraindicated
- Amitriptyline + Vandetanib Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Asenapine + Vandetanib Contraindicated
- Chloroquine + Vandetanib Contraindicated
Frequently asked questions
Can I take Umeclidinium-vilanterol with Vandetanib?
MediHelp rates the interaction as major. Umeclidinium-vilanterol and Vandetanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vandetanib markedly prolongs the QT interval and carries a risk of torsades de pointes. Vilanterol may add to this effect and lower potassium.
How serious is the interaction between Umeclidinium-vilanterol and Vandetanib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible and use an alternative bronchodilator. If unavoidable, monitor ECG, potassium, magnesium and calcium regularly.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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