Drug interactions
Valganciclovir + Voclosporin
Severity: Moderate
Valganciclovir and Voclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin is a calcineurin inhibitor that can cause nephrotoxicity, and reduced renal function increases exposure to ganciclovir, the active form of valganciclovir. This may increase hematologic toxicity of valganciclovir, and combined renal effects may worsen kidney function.
What this interaction means in plain words
Valganciclovir and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Valganciclovir belongs to Anti Virals; Voclosporin belongs to Miscellaneous.
Why it happens
Additive nephrotoxic potential, with reduced renal clearance of ganciclovir.
What to do
Monitor serum creatinine and eGFR regularly, adjust valganciclovir dose to renal function, and monitor blood counts.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Valganciclovir
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Valganciclovir with Voclosporin?
MediHelp rates the interaction as moderate. Valganciclovir and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voclosporin is a calcineurin inhibitor that can cause nephrotoxicity, and reduced renal function increases exposure to ganciclovir, the active form of valganciclovir. This may increase hematologic toxicity of valganciclovir, and combined renal effects may worsen kidney function.
How serious is the interaction between Valganciclovir and Voclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and eGFR regularly, adjust valganciclovir dose to renal function, and monitor blood counts.
What other medicines interact with Valganciclovir?
MediHelp also lists interactions of Valganciclovir with, for example, Didanosine, Ganciclovir, Liposomal doxorubicin. The full list is on the Valganciclovir page.
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