Drug interactions
Valsartan + Voclosporin
Severity: Major
Valsartan and Voclosporin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can raise serum potassium, and voclosporin is nephrotoxic, so combined use increases the risk of hyperkalemia and declining renal function. Close monitoring is required, particularly in patients with reduced kidney function.
What this interaction means in plain words
Valsartan and Voclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Valsartan belongs to Cardiovascular; Voclosporin belongs to Miscellaneous.
Why it happens
Additive reduction of renal potassium excretion (aldosterone suppression plus calcineurin inhibitor effect) combined with calcineurin inhibitor-induced afferent vasoconstriction and ARB efferent dilation, which reduces glomerular filtration.
What to do
Monitor serum potassium and eGFR frequently, especially during initiation and dose changes. Reduce or interrupt voclosporin as per labeling if renal function falls or hyperkalemia develops.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Valsartan
- Aliskiren + Valsartan Contraindicated
- Sparsentan + Valsartan Contraindicated
- Aldesleukin + Valsartan Major
- Amifostine + Valsartan Major
- Amiloride + Valsartan Major
- Amlodipine-benazepril + Valsartan Major
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Valsartan with Voclosporin?
MediHelp rates the interaction as major. Valsartan and Voclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can raise serum potassium, and voclosporin is nephrotoxic, so combined use increases the risk of hyperkalemia and declining renal function. Close monitoring is required, particularly in patients with reduced kidney function.
How serious is the interaction between Valsartan and Voclosporin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and eGFR frequently, especially during initiation and dose changes. Reduce or interrupt voclosporin as per labeling if renal function falls or hyperkalemia develops.
What other medicines interact with Valsartan?
MediHelp also lists interactions of Valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Valsartan page.
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