Drug interactions
Vandetanib + Ziprasidone
Severity: Contraindicated
Vandetanib and Ziprasidone: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vandetanib causes marked, dose-related QT prolongation, and ziprasidone adds to this effect. The combination markedly raises the risk of torsades de pointes and sudden death.
What this interaction means in plain words
Vandetanib and Ziprasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Vandetanib belongs to Oncology; Ziprasidone belongs to Central Nervous System.
Why it happens
Additive delayed cardiac repolarization via hERG channel inhibition.
What to do
Do not combine; select an antipsychotic with minimal QT effect if vandetanib is needed. Monitor ECG, potassium, magnesium and calcium throughout vandetanib therapy.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Other interactions of Vandetanib
- Amiodarone + Vandetanib Contraindicated
- Amisulpride + Vandetanib Contraindicated
- Amitriptyline + Vandetanib Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Asenapine + Vandetanib Contraindicated
- Chloroquine + Vandetanib Contraindicated
Frequently asked questions
Can I take Vandetanib with Ziprasidone?
MediHelp rates the interaction as contraindicated. Vandetanib and Ziprasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Vandetanib causes marked, dose-related QT prolongation, and ziprasidone adds to this effect. The combination markedly raises the risk of torsades de pointes and sudden death.
How serious is the interaction between Vandetanib and Ziprasidone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; select an antipsychotic with minimal QT effect if vandetanib is needed. Monitor ECG, potassium, magnesium and calcium throughout vandetanib therapy.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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