Drug interactions
Venlafaxine + Voriconazole
Severity: Moderate
Venlafaxine and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Venlafaxine is converted to O-desmethylvenlafaxine mainly by CYP2D6, with CYP3A4 as a secondary route. Voriconazole may increase venlafaxine exposure, raising the risk of nausea, hypertension and serotonergic effects. Both agents can also prolong the QT interval.
What this interaction means in plain words
Venlafaxine and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Venlafaxine belongs to Central Nervous System; Voriconazole belongs to Anti Fungals.
Why it happens
Voriconazole inhibits CYP3A4 (and weakly CYP2C19/2D6 routes), reducing venlafaxine clearance, with additive QT effects.
What to do
Monitor blood pressure, heart rate and serotonergic or adverse effects, and lower the venlafaxine dose if needed. Obtain an ECG if other QT risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Frequently asked questions
Can I take Venlafaxine with Voriconazole?
MediHelp rates the interaction as moderate. Venlafaxine and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Venlafaxine is converted to O-desmethylvenlafaxine mainly by CYP2D6, with CYP3A4 as a secondary route. Voriconazole may increase venlafaxine exposure, raising the risk of nausea, hypertension and serotonergic effects. Both agents can also prolong the QT interval.
How serious is the interaction between Venlafaxine and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and serotonergic or adverse effects, and lower the venlafaxine dose if needed. Obtain an ECG if other QT risk factors are present.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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