Drug interactions
Venlafaxine + Vorinostat
Severity: Moderate
Venlafaxine and Vorinostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have been linked to QT prolongation, so concurrent use may add to arrhythmia risk, particularly in patients with electrolyte disturbances or heart disease. The legacy statement of QTc decrease is incorrect; prolongation is the concern.
What this interaction means in plain words
Venlafaxine and Vorinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Venlafaxine belongs to Central Nervous System; Vorinostat belongs to Oncology.
Why it happens
Possible additive effects on cardiac repolarization; no pharmacokinetic mechanism established.
What to do
Monitor ECG and keep potassium and magnesium within normal range during treatment. Consider an alternative antidepressant if significant QTc prolongation develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Other interactions of Vorinostat
- Thioridazine + Vorinostat Contraindicated
- Amiodarone + Vorinostat Major
- Amisulpride + Vorinostat Major
- Anagrelide + Vorinostat Major
- Asenapine + Vorinostat Major
- Chlorpromazine + Vorinostat Major
Frequently asked questions
Can I take Venlafaxine with Vorinostat?
MediHelp rates the interaction as moderate. Venlafaxine and Vorinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have been linked to QT prolongation, so concurrent use may add to arrhythmia risk, particularly in patients with electrolyte disturbances or heart disease. The legacy statement of QTc decrease is incorrect; prolongation is the concern.
How serious is the interaction between Venlafaxine and Vorinostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and keep potassium and magnesium within normal range during treatment. Consider an alternative antidepressant if significant QTc prolongation develops.
What other medicines interact with Venlafaxine?
MediHelp also lists interactions of Venlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Venlafaxine page.
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