Drug interactions
Verapamil + Vinorelbine
Severity: Moderate
Verapamil and Vinorelbine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil inhibits CYP3A4 and P-glycoprotein, which may raise vinorelbine exposure. This could increase myelosuppression and neurotoxicity, although clinical data are limited.
What this interaction means in plain words
Verapamil and Vinorelbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Verapamil belongs to Cardiovascular; Vinorelbine belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated metabolism and P-glycoprotein efflux of vinorelbine by verapamil.
What to do
Monitor blood counts and signs of neuropathy or constipation during combined use. Reduce the vinorelbine dose if excessive toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Vinorelbine
Frequently asked questions
Can I take Verapamil with Vinorelbine?
MediHelp rates the interaction as moderate. Verapamil and Vinorelbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Verapamil inhibits CYP3A4 and P-glycoprotein, which may raise vinorelbine exposure. This could increase myelosuppression and neurotoxicity, although clinical data are limited.
How serious is the interaction between Verapamil and Vinorelbine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and signs of neuropathy or constipation during combined use. Reduce the vinorelbine dose if excessive toxicity develops.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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