Drug interactions
Vilanterol / fluticasone furoate inhaled + Voriconazole
Severity: Moderate
Vilanterol / fluticasone furoate inhaled and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole inhibits CYP3A4, which raises exposure to both vilanterol and fluticasone furoate. This may increase cardiovascular beta-agonist effects, QT prolongation, and systemic corticosteroid effects including adrenal suppression.
What this interaction means in plain words
Vilanterol / fluticasone furoate inhaled and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 inhibition increases vilanterol and fluticasone furoate exposure, plus additive QT effects.
What to do
Monitor heart rate, ECG in at-risk patients, and signs of corticosteroid excess during prolonged use. Consider an alternative inhaled regimen for long-term azole therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Vilanterol / fluticasone furoate inhaled with Voriconazole?
MediHelp rates the interaction as moderate. Vilanterol / fluticasone furoate inhaled and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole inhibits CYP3A4, which raises exposure to both vilanterol and fluticasone furoate. This may increase cardiovascular beta-agonist effects, QT prolongation, and systemic corticosteroid effects including adrenal suppression.
How serious is the interaction between Vilanterol / fluticasone furoate inhaled and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, ECG in at-risk patients, and signs of corticosteroid excess during prolonged use. Consider an alternative inhaled regimen for long-term azole therapy.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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