Drug interactions
Vincristine + Voxelotor
Severity: Major
Vincristine and Voxelotor: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voxelotor can increase exposure to sensitive CYP3A4 substrates. Vincristine is cleared via CYP3A4 and has a narrow therapeutic window, so higher levels could intensify neurotoxicity and constipation or ileus.
What this interaction means in plain words
Vincristine and Voxelotor can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Vincristine belongs to Oncology; Voxelotor belongs to Miscellaneous.
Why it happens
Voxelotor inhibits CYP3A4, reducing the metabolism of vincristine.
What to do
Avoid coadministration if possible. If needed, monitor for neuropathy and gastrointestinal toxicity and consider reducing the vincristine dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Vincristine
- Adenovirus types 4 and 7 live + Vincristine Contraindicated
- Apalutamide + Vincristine Major
- Atazanavir + Vincristine Major
- Ceritinib + Vincristine Major
- Chloramphenicol + Vincristine Major
- Clarithromycin + Vincristine Major
Other interactions of Voxelotor
- Amobarbital + Voxelotor Major
- Apalutamide + Voxelotor Major
- Carbamazepine + Voxelotor Major
- Cyclosporin + Voxelotor Major
- Efavirenz + Voxelotor Major
- Enzalutamide + Voxelotor Major
Frequently asked questions
Can I take Vincristine with Voxelotor?
MediHelp rates the interaction as major. Vincristine and Voxelotor can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Voxelotor can increase exposure to sensitive CYP3A4 substrates. Vincristine is cleared via CYP3A4 and has a narrow therapeutic window, so higher levels could intensify neurotoxicity and constipation or ileus.
How serious is the interaction between Vincristine and Voxelotor?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration if possible. If needed, monitor for neuropathy and gastrointestinal toxicity and consider reducing the vincristine dose.
What other medicines interact with Vincristine?
MediHelp also lists interactions of Vincristine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vincristine page.
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