Drug interactions
Vincristine + Zidovudine
Severity: Minor
Vincristine and Zidovudine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vincristine is only mildly myelosuppressive, but zidovudine can cause anemia and neutropenia, and the combination may add to hematologic toxicity. Both drugs have been associated with neuropathic effects, though this is less established for zidovudine.
What this interaction means in plain words
Vincristine and Zidovudine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Vincristine belongs to Oncology; Zidovudine belongs to Anti Virals.
Why it happens
Additive hematologic toxicity through pharmacodynamic overlap.
What to do
Monitor complete blood counts and neurologic status during combined use. Adjust doses if marked cytopenias occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zidovudine
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Zidovudine Contraindicated
- Stavudine + Zidovudine Contraindicated
- Atidarsagene autotemcel + Zidovudine Major
- Betibeglogene autotemcel + Zidovudine Major
- Carboplatin + Zidovudine Major
- Cisplatin + Zidovudine Major
Other interactions of Vincristine
- Adenovirus types 4 and 7 live + Vincristine Contraindicated
- Apalutamide + Vincristine Major
- Atazanavir + Vincristine Major
- Ceritinib + Vincristine Major
- Chloramphenicol + Vincristine Major
- Clarithromycin + Vincristine Major
Frequently asked questions
Can I take Vincristine with Zidovudine?
MediHelp rates the interaction as minor. Vincristine and Zidovudine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vincristine is only mildly myelosuppressive, but zidovudine can cause anemia and neutropenia, and the combination may add to hematologic toxicity. Both drugs have been associated with neuropathic effects, though this is less established for zidovudine.
How serious is the interaction between Vincristine and Zidovudine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts and neurologic status during combined use. Adjust doses if marked cytopenias occur.
What other medicines interact with Zidovudine?
MediHelp also lists interactions of Zidovudine with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Stavudine, Atidarsagene autotemcel. The full list is on the Zidovudine page.
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