Drug interactions
Vinorelbine + Zafirlukast
Severity: Minor
Vinorelbine and Zafirlukast: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vinorelbine is metabolized mainly by CYP3A4, which zafirlukast may weakly inhibit. A meaningful rise in vinorelbine toxicity is theoretical and not documented.
What this interaction means in plain words
Vinorelbine and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Vinorelbine belongs to Oncology; Zafirlukast belongs to Respiratory.
Why it happens
Possible weak CYP3A4 inhibition by zafirlukast reducing vinorelbine clearance.
What to do
No empiric dose change is needed. Monitor neutrophil counts during therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zafirlukast
- Pimozide + Zafirlukast Contraindicated
- Lomitapide + Zafirlukast Major
- Nilotinib + Zafirlukast Major
- Warfarin + Zafirlukast Major
- Apalutamide + Zafirlukast Moderate
- Carbamazepine + Zafirlukast Moderate
Other interactions of Vinorelbine
Frequently asked questions
Can I take Vinorelbine with Zafirlukast?
MediHelp rates the interaction as minor. Vinorelbine and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vinorelbine is metabolized mainly by CYP3A4, which zafirlukast may weakly inhibit. A meaningful rise in vinorelbine toxicity is theoretical and not documented.
How serious is the interaction between Vinorelbine and Zafirlukast?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empiric dose change is needed. Monitor neutrophil counts during therapy.
What other medicines interact with Zafirlukast?
MediHelp also lists interactions of Zafirlukast with, for example, Pimozide, Lomitapide, Nilotinib. The full list is on the Zafirlukast page.
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