Drug interactions
Voriconazole + Zaleplon
Severity: Minor
Voriconazole and Zaleplon: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole may increase zaleplon exposure and prolong sedation, impairing psychomotor function and next-day alertness. Zaleplon is mainly metabolised by aldehyde oxidase with CYP3A4 as a secondary route, so the effect is generally modest.
What this interaction means in plain words
Voriconazole and Zaleplon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Voriconazole belongs to Anti Fungals; Zaleplon belongs to Central Nervous System.
Why it happens
Voriconazole inhibits CYP3A4, the secondary metabolic pathway of zaleplon.
What to do
Start with the lowest zaleplon dose, 5 mg, and monitor for excessive sedation or dizziness. Advise patients against driving until the response is known.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Zaleplon
- Calcium / magnesium / potassium / sodium oxybates + Zaleplon Contraindicated
- Sodium oxybate + Zaleplon Contraindicated
- Brexanolone + Zaleplon Major
- Buprenorphine long-acting + Zaleplon Major
- Buprenorphine subdermal implant + Zaleplon Major
- Buprenorphine transdermal + Zaleplon Major
Frequently asked questions
Can I take Voriconazole with Zaleplon?
MediHelp rates the interaction as minor. Voriconazole and Zaleplon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Voriconazole may increase zaleplon exposure and prolong sedation, impairing psychomotor function and next-day alertness. Zaleplon is mainly metabolised by aldehyde oxidase with CYP3A4 as a secondary route, so the effect is generally modest.
How serious is the interaction between Voriconazole and Zaleplon?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with the lowest zaleplon dose, 5 mg, and monitor for excessive sedation or dizziness. Advise patients against driving until the response is known.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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