Drug interactions
Voriconazole + Zanubrutinib
Severity: Moderate
Voriconazole and Zanubrutinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole increases zanubrutinib exposure, raising the risk of bleeding, infection, cytopenias and arrhythmia such as atrial fibrillation. Labeling advises a dose reduction with strong CYP3A inhibitors.
What this interaction means in plain words
Voriconazole and Zanubrutinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Voriconazole belongs to Anti Fungals; Zanubrutinib belongs to Oncology.
Why it happens
Strong CYP3A4 inhibition by voriconazole reduces zanubrutinib metabolism and raises its plasma levels.
What to do
Reduce zanubrutinib to 80 mg once daily during voriconazole use and monitor blood counts, bleeding and cardiac rhythm. Resume the usual dose after voriconazole is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Voriconazole and Zanubrutinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Zanubrutinib
Frequently asked questions
Can I take Voriconazole with Zanubrutinib?
MediHelp rates the interaction as moderate. Voriconazole and Zanubrutinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole increases zanubrutinib exposure, raising the risk of bleeding, infection, cytopenias and arrhythmia such as atrial fibrillation. Labeling advises a dose reduction with strong CYP3A inhibitors.
How serious is the interaction between Voriconazole and Zanubrutinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce zanubrutinib to 80 mg once daily during voriconazole use and monitor blood counts, bleeding and cardiac rhythm. Resume the usual dose after voriconazole is stopped.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
