Drug interactions
Voriconazole + Zolpidem
Severity: Moderate
Voriconazole and Zolpidem: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole can increase zolpidem concentrations, leading to more pronounced sedation and psychomotor impairment. Zolpidem is partly cleared by CYP3A4, so strong inhibition raises exposure moderately.
What this interaction means in plain words
Voriconazole and Zolpidem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Voriconazole belongs to Anti Fungals; Zolpidem belongs to Central Nervous System.
Why it happens
Voriconazole inhibits CYP3A4-mediated metabolism of zolpidem.
What to do
Use the lowest effective zolpidem dose and monitor for daytime drowsiness, confusion and complex sleep behaviours. Reduce the dose if sedation is excessive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Zolpidem
Frequently asked questions
Can I take Voriconazole with Zolpidem?
MediHelp rates the interaction as moderate. Voriconazole and Zolpidem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole can increase zolpidem concentrations, leading to more pronounced sedation and psychomotor impairment. Zolpidem is partly cleared by CYP3A4, so strong inhibition raises exposure moderately.
How serious is the interaction between Voriconazole and Zolpidem?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective zolpidem dose and monitor for daytime drowsiness, confusion and complex sleep behaviours. Reduce the dose if sedation is excessive.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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