Drug interactions
Ziprasidone + Zuranolone
Severity: Moderate
Ziprasidone and Zuranolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zuranolone causes somnolence and impaired driving ability, and ziprasidone is also sedating. Together they can increase CNS depression and psychomotor impairment.
What this interaction means in plain words
Ziprasidone and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ziprasidone belongs to Central Nervous System; Zuranolone belongs to Central Nervous System.
Why it happens
Additive CNS depression from GABA-A positive modulation and the sedating receptor effects of ziprasidone.
What to do
Monitor for excessive sedation and consider lowering the zuranolone dose if it occurs. Advise patients not to drive for at least 12 hours after each dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Other interactions of Zuranolone
- Alprazolam + Zuranolone Major
- Amobarbital + Zuranolone Major
- Apalutamide + Zuranolone Major
- Asenapine + Zuranolone Major
- Brexpiprazole + Zuranolone Major
- Butorphanol + Zuranolone Major
Frequently asked questions
Can I take Ziprasidone with Zuranolone?
MediHelp rates the interaction as moderate. Ziprasidone and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zuranolone causes somnolence and impaired driving ability, and ziprasidone is also sedating. Together they can increase CNS depression and psychomotor impairment.
How serious is the interaction between Ziprasidone and Zuranolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and consider lowering the zuranolone dose if it occurs. Advise patients not to drive for at least 12 hours after each dose.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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