تداخل‌های دارویی
Amitriptyline + Atropine
شدت: متوسط
Amitriptyline and Atropine: moderate interaction.
آخرین به‌روزرسانی
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خلاصه
Both drugs have antimuscarinic activity, so combined use can produce additive effects such as dry mouth, constipation, urinary retention, blurred vision and tachycardia. Older patients and those with glaucoma or prostatic hyperplasia are at particular risk.
معنای این تداخل به زبان ساده
Amitriptyline and Atropine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Atropine belongs to Miscellaneous.
چرا رخ می‌دهد
Additive blockade of muscarinic acetylcholine receptors.
اقدام لازم
Monitor for anticholinergic toxicity such as urinary retention, ileus, confusion and tachycardia. Use the lowest effective doses or choose a less anticholinergic alternative in high-risk patients.
از داروساز چه بپرسید
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Amitriptyline و Atropine، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Amitriptyline
- Amitriptyline + Isocarboxazid منع مصرف
- Amitriptyline + Methylene blue منع مصرف
- Amitriptyline + Phenelzine منع مصرف
- Amitriptyline + Pimozide منع مصرف
- Amitriptyline + Procarbazine منع مصرف
- Amitriptyline + Safinamide منع مصرف
تداخلات دیگر Atropine
پرسش‌های متداول
Can I take Amitriptyline with Atropine?
MediHelp rates the interaction as moderate. Amitriptyline and Atropine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have antimuscarinic activity, so combined use can produce additive effects such as dry mouth, constipation, urinary retention, blurred vision and tachycardia. Older patients and those with glaucoma or prostatic hyperplasia are at particular risk.
How serious is the interaction between Amitriptyline and Atropine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity such as urinary retention, ileus, confusion and tachycardia. Use the lowest effective doses or choose a less anticholinergic alternative in high-risk patients.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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