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تداخل‌های دارویی

Atropine + Eluxadoline

شدت: شدید

Atropine and Eluxadoline: major interaction.

آخرین به‌روزرسانی

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محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.

خلاصه

Eluxadoline slows gut transit and can cause constipation and pancreatitis-related events, and atropine adds antimuscarinic suppression of gut motility. Together they raise the risk of severe constipation, ileus and related complications.

معنای این تداخل به زبان ساده

Atropine and Eluxadoline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Atropine belongs to Miscellaneous; Eluxadoline belongs to Gastrointestinal Tract.

سطح شواهد: Moderate

چرا رخ می‌دهد

Additive inhibition of gastrointestinal motility through opioid receptor agonism (eluxadoline) and muscarinic blockade (atropine).

اقدام لازم

Avoid routine coadministration. If an anticholinergic is needed, monitor for constipation and abdominal distension and stop eluxadoline if severe constipation develops.

از داروساز چه بپرسید

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

ویژه اعضای Pro+

باز کردن کل صفحه

یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Atropine و Eluxadoline، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.

پرسش‌های متداول

Can I take Atropine with Eluxadoline?

MediHelp rates the interaction as major. Atropine and Eluxadoline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Eluxadoline slows gut transit and can cause constipation and pancreatitis-related events, and atropine adds antimuscarinic suppression of gut motility. Together they raise the risk of severe constipation, ileus and related complications.

How serious is the interaction between Atropine and Eluxadoline?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine coadministration. If an anticholinergic is needed, monitor for constipation and abdominal distension and stop eluxadoline if severe constipation develops.

What other medicines interact with Atropine?

MediHelp also lists interactions of Atropine with, for example, Henbane, Pramlintide, Abobotulinumtoxina. The full list is on the Atropine page.

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