تداخل‌های دارویی
Amitriptyline + Cocaine
شدت: شدید
Amitriptyline and Cocaine: major interaction.
آخرین به‌روزرسانی
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خلاصه
Cocaine blocks reuptake of norepinephrine, dopamine and serotonin, and tricyclics also block norepinephrine and serotonin reuptake. Combined use can cause exaggerated sympathomimetic effects, arrhythmias, hypertension and seizures. With topical cocaine, systemic absorption is usually small, but the effect can be significant with mucosal application at high doses or in abuse.
معنای این تداخل به زبان ساده
Amitriptyline and Cocaine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amitriptyline belongs to Central Nervous System; Cocaine belongs to Central Nervous System.
چرا رخ می‌دهد
Additive monoamine reuptake inhibition with potentiated adrenergic effects and additive proarrhythmic sodium channel blockade.
اقدام لازم
Avoid cocaine, including recreational use, in patients taking amitriptyline. For medical topical use, use the lowest dose and monitor blood pressure, heart rhythm and ECG.
از داروساز چه بپرسید
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Amitriptyline و Cocaine، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Amitriptyline
- Amitriptyline + Isocarboxazid منع مصرف
- Amitriptyline + Methylene blue منع مصرف
- Amitriptyline + Phenelzine منع مصرف
- Amitriptyline + Pimozide منع مصرف
- Amitriptyline + Procarbazine منع مصرف
- Amitriptyline + Safinamide منع مصرف
تداخلات دیگر Cocaine
- Cocaine + Isocarboxazid منع مصرف
- Cocaine + Phenelzine منع مصرف
- Cocaine + Procarbazine منع مصرف
- Bisoprolol + Cocaine شدید
- Citalopram + Cocaine شدید
- Clomipramine + Cocaine شدید
پرسش‌های متداول
Can I take Amitriptyline with Cocaine?
MediHelp rates the interaction as major. Amitriptyline and Cocaine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cocaine blocks reuptake of norepinephrine, dopamine and serotonin, and tricyclics also block norepinephrine and serotonin reuptake. Combined use can cause exaggerated sympathomimetic effects, arrhythmias, hypertension and seizures. With topical cocaine, systemic absorption is usually small, but the effect can be significant with mucosal application at high doses or in abuse.
How serious is the interaction between Amitriptyline and Cocaine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid cocaine, including recreational use, in patients taking amitriptyline. For medical topical use, use the lowest dose and monitor blood pressure, heart rhythm and ECG.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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