تداخل‌های دارویی
Cocaine + Phenelzine
شدت: منع مصرف
Cocaine and Phenelzine: contraindicated interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Cocaine blocks reuptake of norepinephrine, dopamine and serotonin, while phenelzine prevents breakdown of these amines. Together they can cause marked sympathetic stimulation with severe hypertension, hyperthermia, arrhythmias and serotonin toxicity. Topical cocaine has limited absorption but the combination is still labeled as contraindicated.
معنای این تداخل به زبان ساده
Cocaine and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Cocaine belongs to Central Nervous System; Phenelzine belongs to Central Nervous System.
چرا رخ می‌دهد
Irreversible MAO inhibition plus monoamine reuptake blockade leads to excess synaptic catecholamines and serotonin.
اقدام لازم
Avoid cocaine, including topical anesthetic use, in patients taking phenelzine or within 14 days of stopping it; choose a different local anesthetic. If exposure occurs, monitor blood pressure, heart rate and temperature and treat hypertensive crisis or serotonin toxicity urgently.
از داروساز چه بپرسید
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Cocaine و Phenelzine، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Phenelzine
- 5-HTP + Phenelzine منع مصرف
- Amitriptyline + Phenelzine منع مصرف
- Amoxapine + Phenelzine منع مصرف
- Atomoxetine + Phenelzine منع مصرف
- Benzphetamine + Phenelzine منع مصرف
- Brimonidine + Phenelzine منع مصرف
تداخلات دیگر Cocaine
- Cocaine + Isocarboxazid منع مصرف
- Cocaine + Procarbazine منع مصرف
- Amitriptyline + Cocaine شدید
- Bisoprolol + Cocaine شدید
- Citalopram + Cocaine شدید
- Clomipramine + Cocaine شدید
پرسش‌های متداول
Can I take Cocaine with Phenelzine?
MediHelp rates the interaction as contraindicated. Cocaine and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Cocaine blocks reuptake of norepinephrine, dopamine and serotonin, while phenelzine prevents breakdown of these amines. Together they can cause marked sympathetic stimulation with severe hypertension, hyperthermia, arrhythmias and serotonin toxicity. Topical cocaine has limited absorption but the combination is still labeled as contraindicated.
How serious is the interaction between Cocaine and Phenelzine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid cocaine, including topical anesthetic use, in patients taking phenelzine or within 14 days of stopping it; choose a different local anesthetic. If exposure occurs, monitor blood pressure, heart rate and temperature and treat hypertensive crisis or serotonin toxicity urgently.
What other medicines interact with Phenelzine?
MediHelp also lists interactions of Phenelzine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Phenelzine page.
تک‌نگاری کامل، دوزاژ و بررسی تداخل دارویی در برنامه MediHelp
مرجع کامل را باز کنید، تداخل چند دارو را بررسی کنید و از ابزارهای دوز در برنامه MediHelp استفاده کنید.
