تداخل‌های دارویی
Amoxicillin + Methotrexate
شدت: شدید
Amoxicillin and Methotrexate: major interaction.
آخرین به‌روزرسانی منابع: US FDA label
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Penicillins such as amoxicillin can reduce methotrexate clearance and have been reported to raise methotrexate levels, causing myelosuppression and mucositis. The effect is mainly reported with high-dose methotrexate and in renal impairment, and is less predictable with low-dose therapy. Evidence is based on case reports and pharmacokinetic observations.
معنای این تداخل به زبان ساده
Amoxicillin and Methotrexate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amoxicillin belongs to Anti Bacterial; Methotrexate belongs to Oncology.
چرا رخ می‌دهد
Penicillins compete with methotrexate for renal tubular secretion via organic anion transporters, reducing its elimination.
اقدام لازم
Where possible choose an antibiotic with less renal interaction potential, particularly during high-dose methotrexate. If amoxicillin is needed, monitor full blood count, renal function and methotrexate levels where available.
از داروساز چه بپرسید
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Amoxicillin و Methotrexate، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
منابع
تداخلات دیگر Methotrexate
- Acitretin + Methotrexate منع مصرف
- Adenovirus types 4 and 7 live + Methotrexate منع مصرف
- Influenza virus vaccine quadrivalent intranasal + Methotrexate منع مصرف
- Ketorolac + Methotrexate منع مصرف
- Measles mumps and rubella vaccine live + Methotrexate منع مصرف
- Measles mumps and rubella vaccine + Methotrexate منع مصرف
تداخلات دیگر Amoxicillin
پرسش‌های متداول
Can I take Amoxicillin with Methotrexate?
MediHelp rates the interaction as major. Amoxicillin and Methotrexate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Penicillins such as amoxicillin can reduce methotrexate clearance and have been reported to raise methotrexate levels, causing myelosuppression and mucositis. The effect is mainly reported with high-dose methotrexate and in renal impairment, and is less predictable with low-dose therapy. Evidence is based on case reports and pharmacokinetic observations.
How serious is the interaction between Amoxicillin and Methotrexate?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible choose an antibiotic with less renal interaction potential, particularly during high-dose methotrexate. If amoxicillin is needed, monitor full blood count, renal function and methotrexate levels where available.
What other medicines interact with Methotrexate?
MediHelp also lists interactions of Methotrexate with, for example, Acitretin, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Methotrexate page.
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