تداخل‌های دارویی
Azathioprine + Denosumab
شدت: متوسط
Azathioprine and Denosumab: moderate interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Denosumab has been associated with serious infections, including skin and urinary tract infections, and the risk may be higher in patients on immunosuppressants. Azathioprine adds to this by suppressing lymphocyte proliferation, so the combination can increase infection susceptibility.
معنای این تداخل به زبان ساده
Azathioprine and Denosumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azathioprine belongs to Gastrointestinal Tract; Denosumab belongs to Oncology.
چرا رخ می‌دهد
Additive pharmacodynamic effects on immune function; denosumab inhibits RANKL signalling while azathioprine impairs purine synthesis in lymphocytes.
اقدام لازم
Counsel the patient to report fever or signs of infection promptly and treat infections early. Monitor for infection and review the need for continued immunosuppression if serious infections occur.
از داروساز چه بپرسید
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Azathioprine و Denosumab، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Azathioprine
- Adenovirus types 4 and 7 live + Azathioprine منع مصرف
- Azathioprine + Bcg vaccine live منع مصرف
- Azathioprine + Febuxostat منع مصرف
- Azathioprine + Influenza virus vaccine quadrivalent intranasal منع مصرف
- Azathioprine + Measles mumps and rubella vaccine منع مصرف
- Azathioprine + Measles mumps and rubella vaccine live منع مصرف
تداخلات دیگر Denosumab
- Abatacept + Denosumab متوسط
- Adalimumab + Denosumab متوسط
- Alefacept + Denosumab متوسط
- Alemtuzumab + Denosumab متوسط
- Anakinra + Denosumab متوسط
- Azacitidine + Denosumab متوسط
پرسش‌های متداول
Can I take Azathioprine with Denosumab?
MediHelp rates the interaction as moderate. Azathioprine and Denosumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Denosumab has been associated with serious infections, including skin and urinary tract infections, and the risk may be higher in patients on immunosuppressants. Azathioprine adds to this by suppressing lymphocyte proliferation, so the combination can increase infection susceptibility.
How serious is the interaction between Azathioprine and Denosumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient to report fever or signs of infection promptly and treat infections early. Monitor for infection and review the need for continued immunosuppression if serious infections occur.
What other medicines interact with Azathioprine?
MediHelp also lists interactions of Azathioprine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Febuxostat. The full list is on the Azathioprine page.
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