تداخل‌های دارویی
Azathioprine + Mercaptopurine
شدت: منع مصرف
Azathioprine and Mercaptopurine: contraindicated interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Azathioprine is converted in the body to mercaptopurine, so giving both drugs duplicates the same active thiopurine exposure. This raises the risk of profound myelosuppression, serious infection and hepatotoxicity.
معنای این تداخل به زبان ساده
Azathioprine and Mercaptopurine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Azathioprine belongs to Gastrointestinal Tract; Mercaptopurine belongs to Oncology.
چرا رخ می‌دهد
Therapeutic duplication: azathioprine is a prodrug of mercaptopurine, so both generate the same cytotoxic thioguanine nucleotides.
اقدام لازم
Do not combine the two drugs; use only one thiopurine at a time. If switching, stop one before starting the other and monitor blood counts.
از داروساز چه بپرسید
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Azathioprine و Mercaptopurine، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Mercaptopurine
تداخلات دیگر Azathioprine
- Adenovirus types 4 and 7 live + Azathioprine منع مصرف
- Azathioprine + Bcg vaccine live منع مصرف
- Azathioprine + Febuxostat منع مصرف
- Azathioprine + Influenza virus vaccine quadrivalent intranasal منع مصرف
- Azathioprine + Measles mumps and rubella vaccine منع مصرف
- Azathioprine + Measles mumps and rubella vaccine live منع مصرف
پرسش‌های متداول
Can I take Azathioprine with Mercaptopurine?
MediHelp rates the interaction as contraindicated. Azathioprine and Mercaptopurine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Azathioprine is converted in the body to mercaptopurine, so giving both drugs duplicates the same active thiopurine exposure. This raises the risk of profound myelosuppression, serious infection and hepatotoxicity.
How serious is the interaction between Azathioprine and Mercaptopurine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine the two drugs; use only one thiopurine at a time. If switching, stop one before starting the other and monitor blood counts.
What other medicines interact with Mercaptopurine?
MediHelp also lists interactions of Mercaptopurine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Febuxostat. The full list is on the Mercaptopurine page.
تک‌نگاری کامل، دوزاژ و بررسی تداخل دارویی در برنامه MediHelp
مرجع کامل را باز کنید، تداخل چند دارو را بررسی کنید و از ابزارهای دوز در برنامه MediHelp استفاده کنید.
