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تداخل‌های دارویی

Caplacizumab + Edoxaban

شدت: شدید

Caplacizumab and Edoxaban: major interaction.

آخرین به‌روزرسانی

ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.

محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.

خلاصه

Caplacizumab blocks von Willebrand factor-mediated platelet adhesion and increases bleeding tendency. With edoxaban, the risk of serious bleeding is further increased.

معنای این تداخل به زبان ساده

Caplacizumab and Edoxaban can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Caplacizumab belongs to Cardiovascular; Edoxaban belongs to Cardiovascular.

سطح شواهد: Moderate

چرا رخ می‌دهد

Additive hemostatic impairment from anti-vWF antiplatelet activity and factor Xa inhibition.

اقدام لازم

Consider holding edoxaban during caplacizumab therapy unless a strong indication exists. If both are continued, monitor for bleeding and hemoglobin closely.

از داروساز چه بپرسید

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

ویژه اعضای Pro+

باز کردن کل صفحه

یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Caplacizumab و Edoxaban، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.

پرسش‌های متداول

Can I take Caplacizumab with Edoxaban?

MediHelp rates the interaction as major. Caplacizumab and Edoxaban can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Caplacizumab blocks von Willebrand factor-mediated platelet adhesion and increases bleeding tendency. With edoxaban, the risk of serious bleeding is further increased.

How serious is the interaction between Caplacizumab and Edoxaban?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider holding edoxaban during caplacizumab therapy unless a strong indication exists. If both are continued, monitor for bleeding and hemoglobin closely.

What other medicines interact with Edoxaban?

MediHelp also lists interactions of Edoxaban with, for example, Apixaban, Defibrotide, Ketorolac. The full list is on the Edoxaban page.

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