Drug interactions
Caplacizumab + Edoxaban
Severity: Major
Caplacizumab and Edoxaban: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Caplacizumab blocks von Willebrand factor-mediated platelet adhesion and increases bleeding tendency. With edoxaban, the risk of serious bleeding is further increased.
What this interaction means in plain words
Caplacizumab and Edoxaban can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Caplacizumab belongs to Cardiovascular; Edoxaban belongs to Cardiovascular.
Why it happens
Additive hemostatic impairment from anti-vWF antiplatelet activity and factor Xa inhibition.
What to do
Consider holding edoxaban during caplacizumab therapy unless a strong indication exists. If both are continued, monitor for bleeding and hemoglobin closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Caplacizumab and Edoxaban, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Edoxaban
- Apixaban + Edoxaban Contraindicated
- Defibrotide + Edoxaban Contraindicated
- Edoxaban + Ketorolac Contraindicated
- Abciximab + Edoxaban Major
- Acetylsalicylic acid + Edoxaban Major
- Argatroban + Edoxaban Major
Other interactions of Caplacizumab
Frequently asked questions
Can I take Caplacizumab with Edoxaban?
MediHelp rates the interaction as major. Caplacizumab and Edoxaban can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Caplacizumab blocks von Willebrand factor-mediated platelet adhesion and increases bleeding tendency. With edoxaban, the risk of serious bleeding is further increased.
How serious is the interaction between Caplacizumab and Edoxaban?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider holding edoxaban during caplacizumab therapy unless a strong indication exists. If both are continued, monitor for bleeding and hemoglobin closely.
What other medicines interact with Edoxaban?
MediHelp also lists interactions of Edoxaban with, for example, Apixaban, Defibrotide, Ketorolac. The full list is on the Edoxaban page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
