تداخل‌های دارویی
Digoxin + Furosemide
شدت: شدید
Digoxin and Furosemide: major interaction.
آخرین به‌روزرسانی منابع: US FDA label
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Furosemide can cause hypokalemia and hypomagnesemia, which markedly increase myocardial sensitivity to digoxin and the risk of arrhythmias even at normal serum digoxin concentrations. Volume depletion and reduced renal function from diuresis may also reduce digoxin clearance. The combination is very common in heart failure, so electrolyte monitoring is essential.
معنای این تداخل به زبان ساده
Digoxin and Furosemide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Digoxin belongs to Cardiovascular; Furosemide belongs to Cardiovascular.
چرا رخ می‌دهد
Pharmacodynamic: loop diuretic-induced potassium and magnesium depletion potentiates digoxin's effects on cardiac automaticity and conduction. Pharmacokinetic: volume depletion or acute kidney injury can reduce renal digoxin clearance.
اقدام لازم
Check potassium, magnesium and creatinine at baseline, after starting or changing the furosemide dose, and periodically thereafter. Correct deficits, using potassium supplements, a potassium-sparing diuretic, an ACE inhibitor or an MRA where appropriate.
از داروساز چه بپرسید
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Digoxin و Furosemide، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
منابع
تداخلات دیگر Digoxin
تداخلات دیگر Furosemide
پرسش‌های متداول
Can I take Digoxin with Furosemide?
MediHelp rates the interaction as major. Digoxin and Furosemide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Furosemide can cause hypokalemia and hypomagnesemia, which markedly increase myocardial sensitivity to digoxin and the risk of arrhythmias even at normal serum digoxin concentrations. Volume depletion and reduced renal function from diuresis may also reduce digoxin clearance. The combination is very common in heart failure, so electrolyte monitoring is essential.
How serious is the interaction between Digoxin and Furosemide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check potassium, magnesium and creatinine at baseline, after starting or changing the furosemide dose, and periodically thereafter. Correct deficits, using potassium supplements, a potassium-sparing diuretic, an ACE inhibitor or an MRA where appropriate.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
تک‌نگاری کامل، دوزاژ و بررسی تداخل دارویی در برنامه MediHelp
مرجع کامل را باز کنید، تداخل چند دارو را بررسی کنید و از ابزارهای دوز در برنامه MediHelp استفاده کنید.
