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تداخل‌های دارویی

Digoxin + Penicillamine

شدت: متوسط

Digoxin and Penicillamine: moderate interaction.

آخرین به‌روزرسانی

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خلاصه

Penicillamine has been reported to lower serum digoxin concentrations, which could reduce control of heart rate or heart failure symptoms. The reports are limited and the mechanism is uncertain.

معنای این تداخل به زبان ساده

Digoxin and Penicillamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Digoxin belongs to Cardiovascular; Penicillamine belongs to Musculoskeletal.

سطح شواهد: Low

چرا رخ می‌دهد

Mechanism not established; reduced digoxin absorption has been suggested.

اقدام لازم

Monitor serum digoxin levels and clinical response when penicillamine is started or stopped. Increase the digoxin dose if needed, and separate dosing times.

از داروساز چه بپرسید

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

ویژه اعضای Pro+

باز کردن کل صفحه

یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Digoxin و Penicillamine، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.

پرسش‌های متداول

Can I take Digoxin with Penicillamine?

MediHelp rates the interaction as moderate. Digoxin and Penicillamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Penicillamine has been reported to lower serum digoxin concentrations, which could reduce control of heart rate or heart failure symptoms. The reports are limited and the mechanism is uncertain.

How serious is the interaction between Digoxin and Penicillamine?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum digoxin levels and clinical response when penicillamine is started or stopped. Increase the digoxin dose if needed, and separate dosing times.

What other medicines interact with Penicillamine?

MediHelp also lists interactions of Penicillamine with, for example, Gold sodium thiomalate, Aluminum hydroxide, Calcium carbonate. The full list is on the Penicillamine page.

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