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Domperidone + Omeprazole

شدت: جزئی

Domperidone and Omeprazole: minor interaction.

آخرین به‌روزرسانی

ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.

محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.

خلاصه

Reduced gastric acidity from omeprazole may lower the absorption of domperidone, which needs an acidic environment for dissolution. This may reduce the prokinetic or antiemetic effect. The clinical impact is usually modest, and omeprazole does not meaningfully inhibit CYP3A4 or add to QT risk.

معنای این تداخل به زبان ساده

Domperidone and Omeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.

Domperidone belongs to Gastrointestinal Tract; Omeprazole belongs to Gastrointestinal Tract.

سطح شواهد: Moderate

چرا رخ می‌دهد

Higher gastric pH from proton pump inhibition reduces domperidone dissolution and absorption. It is not mediated through CYP3A4.

اقدام لازم

Give domperidone 15 to 30 minutes before meals as labelled. Review clinical response and adjust therapy if efficacy is reduced.

از داروساز چه بپرسید

  • Is there anything I should notice while taking both?
  • Do I need to tell my doctor at the next visit?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

ویژه اعضای Pro+

باز کردن کل صفحه

یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Domperidone و Omeprazole، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.

منابع

  • Motilium (domperidone) Summary of Product Characteristics — EMA SmPC

پرسش‌های متداول

Can I take Domperidone with Omeprazole?

MediHelp rates the interaction as minor. Domperidone and Omeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Reduced gastric acidity from omeprazole may lower the absorption of domperidone, which needs an acidic environment for dissolution. This may reduce the prokinetic or antiemetic effect. The clinical impact is usually modest, and omeprazole does not meaningfully inhibit CYP3A4 or add to QT risk.

How serious is the interaction between Domperidone and Omeprazole?

MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give domperidone 15 to 30 minutes before meals as labelled. Review clinical response and adjust therapy if efficacy is reduced.

What other medicines interact with Domperidone?

MediHelp also lists interactions of Domperidone with, for example, Azithromycin, Erythromycin, Dexlansoprazole. The full list is on the Domperidone page.

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